Alert

Holiday closures: our outpatient programs will be closed from Dec. 25, 2024 to Jan. 1, 2025. Regular services resume January 2, 2024. Day program will be closed from Dec. 23 to Dec. 27, 2024 inclusive, and will be closed on Jan. 1, 2025. Orthotics and prosthetics will be available for urgent care.

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The Holland Bloorview Research Ethics Board has adopted a national set of REB Standard Operating Procedures called the N2/CAREB REB SOPs.

These SOPs have been developed by the Network of Networks (N2) and the Canadian Association of Research Ethics Boards (CAREB) fully compliant with applicable Canadian and US regulations. 

Some internal practice requirements differ slightly from those described in the N2/CAREB SOPs. As such, SOP addendums that describe the specific HB REB requirements related to applicable N2/CAREB SOP have been created.   The SOP addendums also specify the required REB reporting timelines.

These SOP addendums are to be used in tandem with the N2/CAREB SOPs to ensure compliance.

Standard Operating Procedures

General Administration

pdf-iconSOP 101 Authority and Purpose
pdf-iconSOP 102 Research Requiring REB Review
pdf-iconSOP 102 Research Requiring REB Review Addendum
pdf-iconSOP 103 Training and Education
pdf-iconSOP 104 Management of REB Office Personnel
pdf-iconSOP 105A Conflicts of Interest REB Members and REB Office Personnel
pdf-iconSOP 105A Conflicts of Interest REB Members and REB Office Personnel Addendum
pdf-iconSOP 105B Conflicts of Interest Researcher
pdf-iconSOP 105C Conflicts of Interest Organization
pdf-iconSOP 106 Signatory Authority
pdf-iconSOP 107 Use and Disclosure of Personal Information
pdf-iconSOP 108 Standard Operating Procedures Maintenance
pdf-iconSOP 108 Standard Operating Procedures Maintenance Addendum

REB Organization

pdf-iconSOP 201 Composition of the REB
pdf-iconSOP 202 Management of REB Membership
pdf-iconSOP 203 Duties of REB Members
pdf-iconSOP 203 Duties of REB Members Addendum
pdf-iconSOP 204 Office Personnel Serving as REB Members

Functions and Operations

pdf-iconSOP 301 REB Submission Requirements and Administrative Review
pdf-iconSOP 301 REB Submission Requirement and Administrative Review Addendum
pdf-iconSOP 302 REB Meeting Administration
pdf-iconSOP 302 REB Meeting Administration Addendum
pdf-iconSOP 303 Document Management
pdf-iconSOP 303 Document Management Addendum

Review of Research

pdf-iconSOP 401 Delegated Review
pdf-iconSOP 401 Delegated Review Addendum
pdf-iconSOP 402 REB Review Decisions
pdf-iconSOP 402 REB Review Decisions Addendum
pdf-iconSOP 403 Initial Review Criteria for REB Approval
pdf-iconSOP 403 Initial Review Criteria for REB Approval Addendum
pdf-iconSOP 404 Ongoing REB Review Activities
pdf-iconSOP 404 Ongoing REB Review Activities Addendum
pdf-iconSOP 405 Continuing Review
pdf-iconSOP 405 Continuing Review Addendum
pdf-iconSOP 406 Research Completion
pdf-iconSOP 406 Research Completion Addendum
pdf-iconSOP 407 Suspension or Termination of REB Approval

Reviews Requiring Special Consideration 

pdf-iconSOP 501 REB Review During Publicly Declared Emergencies

Communication and Notifications

pdf-iconSOP 601 Communication Researcher
pdf-iconSOP 602 Communication Research Participants

Informed Consent and Assent

pdf-iconSOP 701 Informed Consent Form Requirements and Documentation
pdf-iconSOP 701 Informed Consent Form Requirements and Documentation Addendum
pdf-iconSOP 706 Informed Consent/Assent Process

Responsibility of Investigators 

pdf-iconSOP 801 Researcher Qualifications and Responsibilities

Quality Management 

pdf-iconSOP 901 Quality Assurance Inspections
pdf-iconSOP 902 External Inspections or Audits
pdf-iconSOP 903 Non-Compliance

Glossary of Terms

pdf-iconGlossary of Terms