Autism Research Centre - Publications

The Autism Research Centre seeks to improve the function and quality of life of children with autism spectrum disorders (ASD or autism) and their families through research.
Click to see Dr. Evdokia Anagnostou's publications on PubMed.
Click to see Dr. Jessica Brian's publications on PubMed.
Click to see Dr. Azadeh Kushki's publications on PubMed.
Here is a selection of their published Autism research results:
Behavioural Intervention
Dr. Jessica Brian
Cauley, K. & Brian, JA. (2004). Teaching play-related verbalizations to children with autism using precision teaching. Journal of Precision Teaching and Celeration, 19(2), 39-42.
Psychopharmacological Intervention
Dr. Evdokia Anagnostou
Smile S, Anagnostou E. (2012) New Models for Considering the Role of Medication in the Treatment and Elucidation of the Etiology of Autism. Curr Psychiatry Rep. PMID:22986996
Hollander E, Soorya L, Chaplin W, Anagnostou E, Taylor BP, Ferretti CJ, Wasserman S, Swanson E, Settipani C.(2012) A double-blind placebo-controlled trial of fluoxetine for repetitive behaviors and global severity in adult autism spectrum disorders. Am J Psychiatry. 2012 Mar;169(3):292-9. Erratum in: Am J Psychiatry. 2012 May;169(5):540.
Anagnostou E, Hansen R. (2011). Medical treatment overview: traditional and novel psycho-pharmacological and complementary and alternative medications. Curr Opin Pediatr. 2011 Dec;23(6):621-7. Review.
Scahill L, McCracken JT, Bearss K, Robinson F, Hollander E, King B, Bregman J, Sikich L, Dukes K, Sullivan L, Anagnostou E, Donnelly C, Kim YS, Ritz L, Hirtz D, Wagner A. (2011). Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders. J Autism Dev Disord. 2011 Jun 11. [Epub ahead of print]
Hollander, E., Chaplin,W., Soorya,L., Wasserman,S., Novotny,S., Rusoff, J., Feirsen, N., Anagnostou. E., Divalproex sodium vs. placebo for the treatment of irritability in Children and adolescents with autism spectrum disorders. Neuropsychopharmacology. 2010 Mar;35(4):990-8.
King, B.H., Hollander, E., Sikich, L., McCracken, J.T., Scahill, L., Bregman, J. D., Donnelly, C.L., Anagnostou, E., Dukes, K., Sullivan,L., Hirtz, D., Wagner, A., Ritz, L., and the STAART Psychopharmacology Network. No effect of Citalopram vs Placebo for Children and Adolescents with Autism Spectrum Disorders and marked levels of repetitive behaviors. Archives of general psychiatry. 2009; 66 (6): 583-590.
Hollander E, Bartz J, Chaplin W, Phillips A, Sumner J, Soorya L, Anagnostou E, Wasserman S. Oxytocin Increases Retention of Social Cognition in Autism. Biol Psychiatry. 2007 15;6:498-503.
Wasserman S, Iyengar R, Chaplin WF, Watner D, Waldoks SE, Anagnostou E, Soorya L, Hollander E. Levetiracetam versus placebo in childhood and adolescent autism: a double-blind placebo-controlled study. Int Clin Psychopharmacol. 2006; 21:363-7.
Anagnostou E., Esposito K., Soorya L., Chaplin W., Wasserman S., Hollander E. Divalproex vs. Placebo Reduces Irritability associated with Fluoxetine administration in autism. Journal of Clinical Psychopharmacology, 2006; 26:444-6.
Anagnostou E, Hollander E. Treatment of repetitive behaviors in autism. Current psychiatry, 2006 5:55-64
Hollander E, Soorya L, Wasserman S, Esposito K, Chaplin W, Anagnostou E. Divalproex sodium vs. placebo in the treatment of repetitive behaviours in autism spectrum disorder. Int J Neuropsychopharmacol. 2006; 9:209-13.
Hollander, E., Swanson, E., Anagnostou, E., Phillips, A., Chaplin, W., Wasserman, S. Liquid fluoxetine vs. placebo for repetitive behaviors in childhood autism. In J. Cummings (Ed.), Progress in Neurotherapeutics and Neuropsychopharmacology. (pp 105-113.). Cambridge University Press. 2006.
Dr. Jessica Brian
Dosman C, Brian J, Drmic I, Senthilselvan A, Harford M, Smith R, Sharieff W, Moldofsky H, Zlotkin S, Roberts W. (2007). Children with autism: Effect of iron supplementation on sleep and ferritin. Pediatric Neurology, 36(3), 152-158.Roberts, W., Weaver, L., Brian, J., Bryson, S., Emelianova, S., Griffiths, A-M., MacKinnon, B., Yim, C., Wolpin, J., & Koren, G. (2001). Repeated doses of porcine secretin in the treatment of autism: A randomized placebo-controlled trial. Pediatrics, E71. Reprinted (2002). Evidence-Based Mental Health, 5, 22.
Neuroimaging
Dr. Evdokia Anagnostou
Doyle-Thomas KA, Duerden EG, Lerch JP, Taylor MJ, Soorya LV, Wang AT, Fan J, Hollander E, Anagnostou E. (2013). Effects of age and symptomatology on cortical thickness in autism spectrum disorders. Research in Autism Spectrum Disorders. 7;1: 141-150.Doyle-Thomas KA, Kushki A, Duerden EG, Taylor MJ, Lerch JP, Soorya LV, Wang AT, Fan J, Anagnostou E. (2012) The Effect of Diagnosis, Age, and Symptom Severity on Cortical Surface Area in the Cingulate Cortex and Insula in Autism Spectrum Disorders. J Child Neurol. PMID:22832774
Mak-Fan KM, Morris D, Vidal J, Anagnostou E, Roberts W, Taylor MJ. (2012) White matter and development in children with an autism spectrum disorder. Autism. PMID:22700988
Ameis SH, Fan J, Rockel C, Voineskos AN, Lobaugh NJ, Soorya L, Wang AT, Hollander E, Anagnostou E. (2011). Impaired structural connectivity of socio-emotional circuits in autism spectrum disorders: a diffusion tensor imaging study. PLoS One. 2011;6(11):e28044.
Girgis RR, Slifstein M, Xu X, Frankle WG, Anagnostou E, Wasserman S, Pepa L, Kolevzon A, Abi-Dargham A, Laruelle M, Hollander E. (2011). The 5-HT(2A) receptor and serotonin transporter in Asperger's disorder: A PET study with [¹¹C]MDL 100907 and [¹¹C]DASB. Psychiatry Res. 2011 Dec 30;194(3):230-4.
Anagnostou E, Taylor MJ. Review of neuroimaging in Autism Spectrum Disorders: what have we learned and where we go from here. Mol Autism. 2011 Apr 18;2(1):4.
Bernardi S, Anagnostou E, Shen J, Kolevzon A, Buxbaum JD, Hollander E, Hof PR, Fan J. In vivo (1)H-magnetic resonance spectroscopy study of the attentional networks in autism. Brain Res. 2010 Dec 22.
Girgis,R., Slifstein, M., Frankle, WG., Anagnostou, E., Wasserman, S., Pepa, L., Kolevzon, A., Abi-Dargham, A., Laruelle, M., & Hollander, E. The 5HT-2A receptor and 5HT transporter in Asperger’s disorder: A PET study with [11C]MDL and [11C]DASB. J Nucl Med. 2010; 51 (Supplement 2):326.
Hollander E, Anagnostou E, Chaplin B, Esposito K, Haznedar M, Licalzi E et al. Striatal Volume on MRI and repetitive behaviors in autism. Biological Psychiatry 2005;58:226-32.
Dr. Jessica Brian
Perez Velazquez JL, Barcelo Hung FY, Leshchenko Y, Nenadovic B, Belkas J, Raghavan V, Brian J, Garcia Dominguez L. (2009). Decreased brain coordinated activity in autism spectrum disorders during executive tasks: Reduced long-range synchronization in the fronto-parietal networks. International J of Psychophysiology, 73, 341-349.Oram Cardy JE, Flagg EJ, Roberts, W, Brian J, Roberts T. MEG identifies rapid temporal processing deficit in autism and language impairment, Neuroreport. 2005; 16(4): 329-332.
Dr. Evdokia Anagnostou & Dr. Jessica Brian
Zwaigenbaum L, Scherer S, Szatmari P, Fombonne E, Bryson S, Hyde K, Anagnostou E, Brian J, Evans A, Hall G, Nicholas D, Roberts, W, Smith I, Vaillancourt T, & Volden J. (2011). The NeuroDevNet Autism Spectrum Disorders Demonstration Project. Seminars in Pediatric Neurology, 18, 40-48.Collaborator: Dr. Wendy S. Roberts
Mak-Fan KM, Taylor MJ, Roberts SW, Lerch JP. Measures of cortical grey matter structure and development in children with Autism Spectrum Disorder. J. Autism Dev. Disord May 2011 (Epub ahead of print) PMID 21556969 CPAOram Cardy JE, Flagg EJ, Roberts W, Roberts TP: Auditory evoked fields predict language ability and impairment in children.Int J Psychophysiology 2008: 68(2): pp 170-5.
Genetics
Dr. Evdokia Anagnostou
Sato D, Lionel AC, Leblond CS, … Anagnostou E, …Roberts W, …Scherer SW. (2012). SHANK1 Deletions in Males with Autism Spectrum Disorder. Am J Hum Genet. 2012 May 4;90(5):879-87.Glessner JT, Wang K, Cai G, Korvatska O, Kim CE, Wood S, Zhang H, Estes A, Brune CW, Bradfield JP, Imielinski M, Frackelton EC, Reichert J, Crawford EL, Munson J, Sleiman PM, Chiavacci R, Annaiah K, Thomas K, Hou C, Glaberson W, Flory J, Otieno F, Garris M, Soorya L, Klei L, Piven J, Meyer KJ, Anagnostou E, Sakurai T, Game RM, Rudd DS, Zurawiecki D, McDougle CJ, Davis LK, Miller J, Posey DJ, Michaels S, Kolevzon A, Silverman JM, Bernier R, Levy SE, Schultz RT, Dawson G, Owley T, McMahon WM, Wassink TH, Sweeney JA, Nurnberger JI, Coon H, Sutcliffe JS, Minshew NJ, Grant SF, Bucan M, Cook EH, Buxbaum JD, Devlin B, Schellenberg GD, Hakonarson H. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature. 2009 May 28;459(7246):569-73. Epub 2009 Apr 28.
Guiqing Cai, Lisa Edelmann, Juliet E Goldsmith, Ninette Cohen, Alisa Nakamine, Jennifer G Reichert, Ellen J Hoffman, Danielle M Zurawiechi, Jeremy M Silverman, Eric Hollander, Latha Soorya, Evdokia Anagnostou, Catalina Betancur and Joseph D Buxbaum. Multiplex ligation-dependent probe amplification for genetic screening in autism spectrum disorders: Efficient identification of known microduplications and identification of a novel microduplication in ASMT. BMC Medical Genomics. 2008, 1;50.
Dr. Jessica Brian
Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Contry J, Magalhaes TR, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bolte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Bryson SE, Carson AR, Casallo G, Casey J, Chung BH, Cochrane L, Corsello C, Crawford EL, Crossett A, Cytrynbaum C, Dawson G, deJonge M, Delorne R, Drmic I, Duketis E, Duque F, Estes A, Fernandez BA, Roberts W, Scherer, SW, Betancur C, et al: Functional impact of global rare copy number variation in autism spectrum disorders. Epub 2010 Jun 9. PMID: 20531469. Nature 2010: 466(7304): pp 368-72.Autism Genome Project Consortium (Szatmari, Paterson, Zwaigenbaum, Roberts, W, Brian, et al.). (2007, February). Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genetics Advance Online.
Collaborator: Dr. Wendy S. Roberts
Chung B, Drmic I, Marshall CR, Grafodatskaya D, Carter M, Fernandez BA, Weksberg R, Roberts SW, Scherer SW: Phenotypic spectrum associated with duplication of Xp11.22-p11.23 includes Autism Spectrum Disorder. Eur J Med Genet 2011 June 17 (Epub ahead of print (PMID 21689796).Noor A, Whibley A, Marshall CR, Gianakopoulos PJ, Piton A, Carson AR, Orlic-Milacic M, Lionel AC, Sata D, Pinto D, Drmic I, Roberts SW, Zwaigenbaum L, Bryson SE, Szatmari P, Scherer SW, Vincent JB....et. al: Disruption at the PTCHD1 locus on Xp22.11 in autism spectrum disorder and intellectual disability.Science Translational Medicine 2010: 15:2(49): pp 49-68.
Berkel S, Marshal CR, Weiss B, Howe J, Roeth R, Moog U, Endris V, Roberts W, Szatmari P, Pinto D, Bonin M, Riess A, Engels H, Sprengel R, Scherer SW, Rappold GA: Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation.Epub 2010 May 16, PMID: 20473310.Nat Genet. 2010: 42 (6): pp 489-91.
Noor A, Gianakopoulos PJ, Fernandez B, Marshall C, Scherer SW, Szatmari P, Roberts SW, Vincent JB,: Copy number variation analysis and sequencing of the X-linked mental retardation geneTSPAN7/TM4SF2 in patients with Autism Spectrum Disorder.Psychiatric Genetics 2009: 19(3): pp 154-155.
Fernandez BA, Roberts SW, Chung B, Weksberg R, Meyn S, Szatmari P, Joseph-George AM, Mackay S, Whitten K, Noble B, Vardy C, Crosbie V, Luscombe S, Tucker E, Turner L, Marshall CR, Scherer SW: Phenotypic spectrum associated with de novo and inherited deletions and duplications at 16p11.2 in individuals ascertained for diagnosis of Autism Spectrum Disorder.J Med Genet (Epub ahead of print) 2009.
Marshall CR, Noor A, Vincent JB, Lionel AC, Feuk L, Skaug J, Baatjes R, Zwaigenbaum L, Roberts W, Fernandez B, Szatmari, P, Scherer SW.......et. al: Structural variation of chromosomes in autism spectrum disorder.Am J Hum Genet. 2008: 82(2): pp 477-88.
Vincent JB, Noor A, Scherer SW, Roberts W, Wagner K, Kroisel PM, Petek E, Windpassinger C, Glanakopoulos P, Schwarzbraun T. Petek E, Alfred SE, Stachowlak B: Characterization of a de novo translocation t (5;18) (q33.1;q12.1) in an autistic boy identifies a breakpoint close to SH3TCZ, ADRB2, and HTR4 on 5q, and within the desmocollin gene cluster on 18q.American Journal of Medical Genetics B, Neuropsychiatric Genetics 2008.
Ickowicz A, Feng Y, Wigg K, Quist J, Pathare T, Roberts W, Malone M, Schachar R, Tannock R, Kennedy JL, Barr CL: Serotonin receptor HTR1B - gene polymorphisms in attention deficit hyperactivity disorder.Neuropsychiatric Genetics 2007: 144B, 1: pp 121-125.
Scherer SW, Szatmari P, Roberts W: (The Autism Genome Project Consortium): Mapping autism risk loci using genetic linkage and chromosomal rearrangements.Nature Genetics 2007: 39(3): pp 319-328.
Bonati MT, Russo S, Finelli P, Valsecchi MR,Cogliati F, Cavalleri F, Roberts W, Elia M, Larizza L: Evaluation of autism traits in Angelmans syndrome: a resource to unfold autism genes.Neurogenetics 2007: 8(3): pp 169-78.
Moessner R,Marshall CR, Sutcliffe JS, Skaug J, Pinto D, Vincent J, Zwaigenbaum L, Fernandez B, Roberts W, Szatmari P, Scherer SW: Contribution of SHANK3 mutations to autism spectrum disorder.American Journal of Human Genetics 2007: 81(6): pp 1289-97.