A Pilot Study of Riluzole vs. Placebo in the Treatment of Children and Adolescents with ASD

Medication Clinical Trials


The purpose of the study is to examine the safety and effects of riluzole vs. placebo for the treatment of autism spectrum disorder (ASD) symptoms (e.g., social function, repetitive behaviours, anxiety, irritability, and hyperactivity) in children and adolescents with ASD.


Evdokia Anagnostou, MDJessica Brian, PhDSharon Smile

Who can participate

- 6-17 years old with ASD

- Already participated in early stages of POND

- Can tolerate venipuncture and swallowing of pills

- Parent (and child/adolescent if verbal) fluency in English

What's Involved

This is a 4-month pilot study of riluzole in ASD. You and your child will be asked to come in for a screening session, through talking with you and completing some assessments we will determine if your child meets eligibility criteria. If your child meets criteria, then you will receive either riluzole or placebo. A placebo is a fake drug that looks, smells, and tastes like the actual drug, but is not the drug at all. You will be asked to come back to Holland Bloorview every two weeks for visits for 3 months while your child is taking the drug.

Interested in participating

Recruitment is closed at this time.

Funding Agency

Ontario Brain Institute (OBI)

Learn more about this study