A Pilot Dose Finding Study of Pioglitazone in Children with ASD

Medication Clinical Trials


To determine the best dose of pioglitazone for children with autism spectrum disorder, whether pioglitazone is safe and effective, what its side effects are, and if it can improve core symptoms of ASD (e.g., social function, repetitive behaviours, anxiety, irritability, and hyperactivity). We do not know whether pioglitazone works for children and youth with ASD. This is why we are doing this research study.


Evdokia Anagnostou, MDJessica Brian, PhDSharon Smile

Who can participate

  • 5-12 years old with ASD
  • Can tolerate venipuncture and swallowing of pills
  • Parent (and child/adolescent if verbal) fluency in English

What's Involved

This is a four-month pilot dose-finding study of pioglitazone in children with ASD. You and your child will be asked to come in for a screening session. At this visit, we will talk with you and your child, complete some behavioural tests and determine if your child can safely participate in our research. If your child meets eligibility criteria, he/she will be given a daily dose of pioglitazone for the duration of the study. You and your child will visit Holland Bloorview every two to four weeks during this time so that our research physicians can monitor your child’s progress.

Interested in participating

Recruitment is closed at this time

Funding Agency

Physician Services Incorporated (PSI) and University of Toronto, Deans Fund

Download Flyer

Learn more about this study

Learn more about this study