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Approach

The workhorse in our research is multimodal Magnetic Resonance Imaging of brain structure and function (MRI). Insights about genetic underpinnings of various MR-derived phenotypes are gained through large Genome-wide Association Studies (GWAS). Dynamics of gene expression, as it relates to MRI-derived phenotypes, such as cortical thickness, is revealed by integrating data from the Allen Human Brain Atlas and the BrainSpan Atlas. Epigenetic signatures are explored via Epigenome-wide Association Studies. Influences of social and physical environment are studied through geo-spatial links between aggregate data (e.g., green space or income inequality in a neighbourhood) and health data obtained from our participants.